Announcements

Semi-Annual Reconstitution (Final) - June 2022

June 13, 2022

LifeSci Biotechnology Products Index

LifeSci Biotechnology Clinical Trials Index

Index Semi-Annual Reconstitution (Final)

The LifeSci Biotechnology Products Index and the LifeSci Biotechnology Clinical Trials Index will be reconstituted as of the market open on Thursday, June 16, 2022. All positions will be equally weighted, with weights determined as of the closing prices on Tuesday, June 14, 2022. The final changes are summarized below.

LifeSci Biotechnology Clinical Trials Index (121 components as adjusted)

Additions (8 stocks):

DSGN, EQRX, FHTX, LYEL, PCVX, PNT, SRRA, VTYX

Deletions (66 stocks):

ACIU, ADAP, AKBA, ALDX, ALGS, ALLK, ALVR, AMTI, ANNX, AUTL, BCAB, CGEN, CLVS, CMRX, CNTA, COGT, CRIS, CRTX, CTMX, CUE, CVM, DTIL, EPIX, EVLO, FDMT, FIXX, FMTX, FULC, GRCL, GRPH, GRTS, GTHX, HGEN, KALV, KNTE, KRON, LXRX, MEIP, MGNX, MRNS, OLMA, ORIC, PASG, PLRX, PRAX, PRVB, RUBY, RYTM, SELB, SRRK, STRO, STTK, TCRT, TSHA, VBIV, VKTX, VOR, VSTM (no longer fit market cap and/or trading volume criteria)
AXSM, BBIO, IMCR, LEGN, MIRM, MYOV, ROIV (being moved to Products Index based on FDA approval)
TPTX (being acquired)

LifeSci Biotechnology Products Index (52 components as adjusted)

Additions (9 stocks):

AXSM, BBIO, IMCR, LEGN, MIRM, MYOV, ROIV (being moved from Clinical Trials Index)
CTIC, DCPH (newly fit criteria)

Deletions (5 stocks):

ADCT, BLUE, TSVT, YMAB (no longer fit market cap and/or trading volume criteria)
BHVN (being acquired)

The LifeSci Biotechnology Indexes are equal-weighted indexes that track the performance of U.S.-listed biotechnology stocks in two distinct stages in the lifecycle of biotechnology companies – Clinical Trials stage and Product stage. The indexes are calculated with a base value of 1,000 as of June 30, 2004 and have an official inception date of November 3, 2014.

LifeSci Biotechnology Clinical Trials Index – All Components (Final) as of June 16, 2022

ABCL, ABUS, ACET, ADGI, AFMD, AGEN, AKRO, ALEC, ALLO, ALXO, AMRS, ANAB, ARCT, ARQT, ARVN, ARWR, ATAI, ATHA, ATRA, AVIR, BCYC, BTAI, CARA, CCCC, CDXS, CERE, CGEM, CLDX, CMPS, CRBU, CRNX, CRSP, CVAC, CYTK, DAWN, DICE, DNLI, DSGN, DVAX, EDIT, EQRX, ERAS, EWTX, FATE, FGEN, FHTX, GERN, GHRS, GOSS, IBRX, IDYA, IGMS, IMAB, IMGN, IMGO, IMVT, INBX, INO, IOVA, ISEE, ITOS, KDNY, KOD, KROS, KRTX, KRYS, KURA, KYMR, KZR, LYEL, MCRB, MDGL, MGTX, MORF, MRSN, MRTX, MRUS, NGM, NKTX, NRIX, NTLA, NUVB, NVAX, PCVX, PGEN, PHAT, PMVP, PNT, PRLD, PRTA, PTGX, QURE, RAPT, RCKT, RCUS, REPL, RETA, RGNX, RLAY, RLMD, RNA, RPTX, RVMD, RXDX, RXRX, SAVA, SGMO, SNDX, SRNE, SRRA, STOK, SWTX, TGTX, TIL, VIR, VTYX, VXRT, XENE, XNCR, ZNTL, ZYME

LifeSci Biotechnology Products Index – All Components (Final) as of June 16, 2022

ACAD, AGIO, ALNY, AMGN, APLS, ASND, AUPH, AXSM, BBIO, BCRX, BGNE, BIIB, BMRN, BNTX, BPMC, CCXI, CTIC, DCPH, ENTA, EXEL, FOLD, GBT, GILD, HALO, HRMY, IMCR, INCY, INSM, IONS, IRWD, ITCI, KNSA, LEGN, LGND, MIRM, MRNA, MYOV, NBIX, NKTR, PTCT, RARE, REGN, ROIV, SAGE, SGEN, SRPT, TBPH, TVTX, UTHR, VNDA, VRTX, ZLAB

For more information, visit www.lifescietf.com